Pharmaceutical industry - Drug Development, Regulation, Research

pharmaceutical industry

Table of Contents

Introduction
History
- The origin of medicines
  - Medicines of ancient civilizations
  - Pharmaceutical science in the 16th and 17th centuries
- Isolation and synthesis of compounds
- The development of anti-infective agents
  - Discovery of antiseptics and vaccines
  - Improvement in drug administration
- Drug development in the 19th and 20th centuries
  - New classes of pharmaceuticals
  - Transitions in drug discovery
- Establishing the fight against infectious disease
  - Early efforts in the development of anti-infective drugs
  - Discovery of penicillin
- Discovery and development of hormones and vitamins
  - Isolation of insulin
  - Identification of vitamins
- Emergence of modern diseases and treatment
  - Hypertension
  - Early progress in cancer drug development
  - Pharmaceutical industry in the modern era
Drug discovery and development
- Drug development process
  - Research and discovery
  - Contribution of scientific knowledge to drug discovery
- Drug screening
  - Sources of compounds
  - Lead chemical identification
    - Lead compounds from natural products
    - Taxol and the Pacific yew
- Strategies for drug design and production
  - Structure-activity relationship
  - Computer-aided design of drugs
  - Combinatorial chemistry
  - Synthetic human proteins
Drug regulation and approval
- Regulation by government agencies
  - Public influence on drug regulation
  - Objectives and organization of drug regulatory agencies
- Drug approval processes
  - Drug applications
    - The Investigational New Drug application
    - The New Drug Application
  - Safety testing in animals
    - Toxicity tests
    - Teratogenicity and mutagenicity tests
  - Biopharmaceutical studies
    - Pharmacokinetic investigation
    - Dosage form development
      Tablets
      Capsules
      Other solid dosage forms
      Liquid dosage forms
      Semisolid dosage forms
      Specialized dosage forms
      Modified-release dosage forms
      Parenteral dosage forms
      Radiopharmaceuticals
Obstacles in drug development
- Adverse reactions
- Postmarketing adverse drug events
- Drug interactions
- Drug patents

References & Edit History Related Topics

Images & Videos

Know about penicillin's discovery by Alexander Fleming and development by Ernst Chain and Howard Florey and its success in treating the wounded in World War II

research and discovery processes used for drug development

Observe the subtle effects of the anticancer drug Taxol inside a cell

For Students

pharmaceutical industry summary

Read Next

Artwork for themes for Pro-Con articles.

Pro and Con: Prescription Drug Costs

Abstract vector hi speed internet technology background

History of Technology Timeline

Binary Computer Code, Binary Code, Internet, Technology, Password, Data

How Does Wi-Fi Work?

Discover

Albert Einstein in Washington, D.C. c. 1921-1923. Physicist

The Solar Eclipse That Made Albert Einstein a Science Celebrity

Aphrodite. Greek mythology. Sculpture. Aphrodite is the Greek goddess of love and beauty.

12 Greek Gods and Goddesses

solar eclipse, sun, moon, astronomy, space

How Do You Tell the Difference Between Total, Annular, Solar, and Lunar Eclipses?

Two chicks near an egg with a white background (poultry, chick, chickens, birds).

What Do Eggs Have to Do with Easter?

How Is Coffee Decaffeinated?

Still from the film Deliverance, 1919. The story of Helen Keller and Anne Sullivan. View shows Keller in the cockpit/front seat of an airplane.

How Did Helen Keller Fly a Plane?

In this aerial photo, structures are damaged and destroyed October 15, 2005 in Balakot, Pakistan. It is estimated that 90% of the city of Balakot was leveled by the earthquake. The death toll in the 7.6 magnitude earthquake that struck northern Pakistan on October 8, 2005 is believed to be 38,000 with at least 1,300 more dead in Indian Kashmir. SEE CONTENT NOTES.

6 of the World’s Deadliest Natural Disasters

Adverse drug events are unanticipated or unwanted effects of drugs. In general, adverse drug reactions are of two types, dose-dependent and dose-independent. When any drug is administered in sufficiently high dose, many individuals will experience a dose-dependent drug reaction. For example, if a person being treated for high blood pressure (hypertension) accidentally takes a drug dose severalfold higher than prescribed, this person will probably experience low blood pressure (hypotension), which could result in light-headedness and fainting. Other dose-dependent drug reactions occur because of biological variability. For a variety of reasons, including heredity, coexisting diseases, and age, different individuals can require ...(100 of 13439 words)

Access the full article

Help support true facts by becoming a member.